Breakthrough Natural Biological Fermentation: Salecan® Next-Generation High-Performance beta-Glucan

Amidst the global trends of sensitive skin repair and skin barrier care, Salecan® beta-glucan—a revolutionary ingredient derived from marine microorganisms—is leading the beauty industry into a new era of "high efficacy, high safety, and sustainability." As the world’s first natural, water-soluble beta-glucan obtained through biological fermentation, Salecan® distinguishes itself from traditional plant-derived beta-glucans extracted from cell walls. Its unique linear structure and exceptional biological activity provide superior repair capabilities and a luxurious sensory experience for personal care products.
 

Basic Information

• Product Name: Salecan® beta-Glucan

• INCI Name: Beta-Glucan

• CAS Code: 1439905-58-4

• Main Functions: Skin barrier repair, anti-inflammatory and soothing, deep moisturization, skin microbiota regulation, and sun protection assistance.

• Applicable Products: Serums, lotions, creams, masks, toners, as well as oral and hair care products.

Core Technical Advantages

1. Exclusive Marine Microbial Fermentation for a Pure, Natural Structure Unlike traditional β-glucans extracted from yeast or oat cell walls, Salecan® is derived from the extracellular polysaccharides secreted by the marine microorganism Rhizobium pusense ZX09. Produced through a gentle biological fermentation process and utilizing non-carboxymethylation technology, Salecan® ensures the integrity of its original linear structure. This maintains the bioactivity required for immune regulation while achieving 100% natural, transparent, and water-soluble advantages.

2. Clinically Proven Anti-Inflammatory and Repair Efficacy In LPS-induced inflammation models and fibroblast proliferation experiments, Salecan® has demonstrated potent repair efficacy:

• Significant Anti-inflammatory Effects: It effectively inhibits inflammatory factors such as IL-6 and TNF-α, helping to soothe sensitive skin and enhance the skin's defense system.

• Promotion of Collagen Synthesis: It significantly promotes Type I collagen secretion and continuously accelerates fibroblast proliferation within 24–72 hours, aiding in the reconstruction of damaged barriers for firmer, more elastic skin.
  
  

3. Superior Sensory and Physical Properties Salecan® offers unique viscosity properties. Compared to common yeast, oat, or mushroom-derived β-glucans, its aqueous solution provides excellent clarity and a refreshing, smooth skin feel. This makes it an ideal ingredient for premium skincare, offering both improved skin texture and long-lasting, refreshing hydration.

Why Choose Salecan®?

As more than just a moisturizer, Salecan® is a scientifically validated repair factor:

• 100% Water Soluble: It eliminates the formulation challenges associated with water-insoluble β-glucans, providing products with exceptional clarity and texture.

• Unique Linear Structure: By preserving the original linear structure without carboxymethylation, it ensures both safety and high ingredient activity.

• Comprehensive Applications: Suitable for various systems including serums, lotions, and creams, with regulatory support including EU Novel Food status and US GRAS certification.

Rigorous Cellular Research Supporting Efficacy

We have conducted extensive cellular studies demonstrating Salecan®’s efficacy in soothing, moisturizing, and repairing the skin:

1. Deep Moisturizing and Barrier Repair In 3D human epidermal model studies, Salecan® significantly enhanced the expression of key moisture-regulating proteins:

• Hyaluronic Acid (HA) secretion increased by 150.00%

• Filaggrin (FLG) expression increased by 100.00%

• Aquaporin-3 (AQP3) expression increased by 111.11%
  
  

2. A "Soothing Shield" for Sensitive Skin Salecan® provides effective inhibition against common sensitive skin triggers:

• HMGB1 Inhibition: In inflammation models, Salecan® significantly reduced the levels of HMGB1 (an inflammatory marker), alleviating inflammatory responses.
  
  

• Pain Relief: In TRPV1 (the receptor for pain and heat sensation) over-activation tests, Salecan® demonstrated a 37.11% inhibition rate, effectively reducing discomfort caused by external stimuli.